Barbaloin inhibits ventricular arrhythmias in rabbits by modulating voltage-gated ion channels

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Voltage-gated ion channels

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Voltage-Gated Lipid Ion Channels

Synthetic lipid membranes can display channel-like ion conduction events even in the absence of proteins. We show here that these events are voltage-gated with a quadratic voltage dependence as expected from electrostatic theory of capacitors. To this end, we recorded channel traces and current histograms in patch-experiments on lipid membranes. We derived a theoretical current-voltage relation...

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Cardiac Mechano-Gated Ion Channels and Arrhythmias.

Mechanical forces will have been omnipresent since the origin of life, and living organisms have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The cardiovascular system in general, and the heart in particular, is exposed to constantly changing mechanical signals, including stretch, compression, bending, and shear. The heart adjusts its performance to the mechanical ...

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Modeling of voltage-gated ion channels Modeling of voltage-gated ion channels

The recent determination of several crystal structures of voltage-gated ion channels has catalyzed computational efforts of studying these remarkable molecular machines that are able to conduct ions across biological membranes at extremely high rates without compromising the ion selectivity. Starting from the open crystal structures, we have studied the gating mechanism of these channels by mol...

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ژورنال

عنوان ژورنال: Acta Pharmacologica Sinica

سال: 2017

ISSN: 1671-4083,1745-7254

DOI: 10.1038/aps.2017.93